Chat with your own documents: AnythingLLM, from Mintplex Labs, wraps retrieval-augmented generation (RAG) in an open-source application anyone can run. You organize content into workspaces, each an isolated namespace with its own documents, vector embeddings, chat history, and settings, so one instance can hold several separate knowledge bases. Upload PDFs, DOCX, TXT, and other formats, or scrape web pages; the built-in collector parses and chunks them into a vector database (LanceDB by default, with Pinecone, Chroma, Qdrant, and others supported). Answers cite their source documents. It works with both cloud LLMs (OpenAI, Anthropic, Gemini) and local ones via Ollama or LM Studio, and the embedding model is separately configurable. Beyond RAG chat, it includes AI agents that can browse the web and run tools, an embeddable chat widget for your website, a developer API, and multi-user mode with admin, manager, and default roles plus per-workspace access control. Context assembly is smarter than naive RAG: pinned documents, attached files, vector search hits, and recent chat history are combined under a token budget so the model's context window is filled efficiently, and each workspace supports multiple independent conversation threads against the same knowledge base. Because the embedding model, vector store, and chat LLM are all independently swappable, you can move between providers without re-ingesting a single document. The stack is Node.js with a React frontend, MIT-licensed.

A self-hosted "second brain": Khoj indexes your own files and answers questions from them, parsing Markdown (whole Obsidian vaults included), org-mode, PDF, Word, plain text, Notion pages, GitHub repositories, and images described by a vision model, then embedding everything with sentence-transformers into a vector index for semantic search and RAG with cited sources. Any LLM backend works: local models like Llama, Qwen, or Mistral via Ollama, or cloud models like GPT, Claude, and Gemini. You can build custom agents, each with its own persona, scoped knowledge base, chat model, and tools such as web search and code execution. Scheduled automations run recurring research and deliver newsletters or notifications to your inbox, and research mode performs multi-hop web searches with inline citations. Access it from a browser, the Obsidian plugin, Emacs, desktop, or WhatsApp - all clients connect to the same self-hosted instance, making Khoj one of the few AI assistants Emacs users can point at decades of org files. Semantic search means recall works without exact keywords: "that paper about forecasting with transformers" surfaces the right PDF even when you cannot remember its title. Switching LLM backends never requires re-indexing your documents, and with a local model via Ollama, even inference stays on hardware you control - journals, research, and private notes are never sent anywhere. Python/FastAPI stack, AGPL-licensed, with PostgreSQL storage.

With over 6,500 GitHub stars, HolaOS bills itself as an "open agent computer" that reimagines the traditional operating system as a shared workspace where humans and AI agents collaborate across files, browsers, and 100+ integrated tools simultaneously. Unlike chat-only interfaces, HolaOS places live application UIs—Notion-style editors, browsers, custom workspace apps—side by side with the agent conversation, so operators always see what agents are doing and can intervene at any moment. The persistent memory system stores workspace knowledge locally as Markdown files and embedded vectors via SQLite vec, enabling RAG-powered recall that survives session boundaries without the typical context window bloat. Safe Session Compaction reserves roughly 70% of the model context window for fresh reasoning while folding older history into structured checkpoints that retain goals, constraints, progress, and decisions. Agents connect to Linear, GitHub, Slack, Jira, HubSpot, Gmail, and dozens more through one-click OAuth, automatically fetching relevant signals and converting scattered app data into working memory. BYOK support for Claude, GPT, and Gemini models lets operators use their own API keys at zero markup, while built-in Kimi K3 and GLM-5.2 models provide ready-to-use alternatives. Skills package reusable workflows that any agent can invoke on demand, and scheduled triggers enable autonomous digests, monitors, and reports. The runtime supports independent server deployment alongside the desktop client. Running on a dedicated VPS on RepoCloud with guaranteed CPU, RAM, and SSD, full root SSH access, and a browser serial console. Modified Apache 2.0 licensed.